{"id":1868,"date":"2026-02-07T19:50:12","date_gmt":"2026-02-07T10:50:12","guid":{"rendered":"https:\/\/dev.rftcjapan.org\/?page_id=1868"},"modified":"2026-02-27T13:21:55","modified_gmt":"2026-02-27T04:21:55","slug":"brca1-and-brca2-mutations-in-men","status":"publish","type":"page","link":"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-men\/","title":{"rendered":"BRCA1 and BRCA2 Mutations in Men"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1868\" class=\"elementor elementor-1868\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-847b1a3 e-flex e-con-boxed e-con e-parent\" data-id=\"847b1a3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c92b56e e-con-full elementor-hidden-mobile e-flex e-con e-child\" data-id=\"c92b56e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-9aa8821 e-con-full e-flex e-con e-child\" data-id=\"9aa8821\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;],&quot;sticky_offset&quot;:100,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c4dfa11 elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"c4dfa11\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;numbers&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t\t\t\t<h2 class=\"elementor-toc__header-title\">\n\t\t\t\tTable of Contents\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__c4dfa11\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__c4dfa11\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div id=\"elementor-toc__c4dfa11\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<svg class=\"elementor-toc__spinner eicon-animation-spin e-font-icon-svg e-eicon-loading\" aria-hidden=\"true\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M500 975V858C696 858 858 696 858 500S696 142 500 142 142 304 142 500H25C25 237 238 25 500 25S975 237 975 500 763 975 500 975Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5369cf0 elementor-widget elementor-widget-heading\" data-id=\"5369cf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">About Breast Cancer<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-369a6d0 elementor-widget elementor-widget-template\" data-id=\"369a6d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"3044\" class=\"elementor elementor-3044\" data-elementor-post-type=\"elementor_library\">\n\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2330\" class=\"elementor-element elementor-element-fd830c6 e-con-full e-grid e-con e-child\" data-id=\"fd830c6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2330\" class=\"elementor-element elementor-element-3717cd6 e-con-full e-flex e-con e-child\" data-id=\"3717cd6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e6c4d06 elementor-widget elementor-widget-heading\" data-id=\"e6c4d06\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Breast Cancer Basics<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c84b33f elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"c84b33f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i aria-hidden=\\&quot;true\\&quot; class=\\&quot;\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"\u30e1\u30cb\u30e5\u30fc\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none\">\n\t\t\t\t<ul id=\"menu-1-c84b33f\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2517\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/what-is-breast-cancer\/\" class=\"elementor-item\">What is Breast Cancer?<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2515\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/breast-cancer-statistics-global-japan\/\" class=\"elementor-item\">Breast Cancer Statistics (Global &amp; Japan)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2516\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/understanding-the-risk-of-breast-cancer\/\" class=\"elementor-item\">Understanding the Risk of Breast Cancer<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-c84b33f\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2517\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/what-is-breast-cancer\/\" class=\"elementor-item\" tabindex=\"-1\">What is Breast Cancer?<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2515\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/breast-cancer-statistics-global-japan\/\" class=\"elementor-item\" tabindex=\"-1\">Breast Cancer Statistics (Global &amp; Japan)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2516\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/understanding-the-risk-of-breast-cancer\/\" class=\"elementor-item\" tabindex=\"-1\">Understanding the Risk of Breast Cancer<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2330\" class=\"elementor-element elementor-element-67a9bd1 e-con-full e-flex e-con e-child\" data-id=\"67a9bd1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed0de9e elementor-widget elementor-widget-heading\" data-id=\"ed0de9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Diagnosis &amp; Staging<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c981917 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"c981917\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"\u30e1\u30cb\u30e5\u30fc\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none\">\n\t\t\t\t<ul id=\"menu-1-c981917\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2521\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/signs-and-symptoms\/\" class=\"elementor-item\">Signs and Symptoms<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2522\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/the-stages-of-breast-cancer\/\" class=\"elementor-item\">The Stages of Breast Cancer<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2523\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/tumor-size-and-staging\/\" class=\"elementor-item\">Tumor Size and Staging<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2520\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/metastases-and-staging\/\" class=\"elementor-item\">Metastases and Staging<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2519\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/early-stage-breast-cancers-non-invasive\/\" class=\"elementor-item\">Early-Stage Breast Cancers (Non-invasive)<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-c981917\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2521\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/signs-and-symptoms\/\" class=\"elementor-item\" tabindex=\"-1\">Signs and Symptoms<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2522\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/the-stages-of-breast-cancer\/\" class=\"elementor-item\" tabindex=\"-1\">The Stages of Breast Cancer<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2523\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/tumor-size-and-staging\/\" class=\"elementor-item\" tabindex=\"-1\">Tumor Size and Staging<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2520\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/metastases-and-staging\/\" class=\"elementor-item\" tabindex=\"-1\">Metastases and Staging<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2519\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/early-stage-breast-cancers-non-invasive\/\" class=\"elementor-item\" tabindex=\"-1\">Early-Stage Breast Cancers (Non-invasive)<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2330\" class=\"elementor-element elementor-element-dd578e0 e-con-full e-flex e-con e-child\" data-id=\"dd578e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6342a8d elementor-widget elementor-widget-heading\" data-id=\"6342a8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Risk Factors &amp; Genetics<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-857c29f elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"857c29f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"\u30e1\u30cb\u30e5\u30fc\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none\">\n\t\t\t\t<ul id=\"menu-1-857c29f\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2525\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-men\/\" class=\"elementor-item\">BRCA1 and BRCA2 Mutations in Men<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2526\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-women\/\" class=\"elementor-item\">BRCA1 and BRCA2 Mutations in Women<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2528\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/lobular-carcinoma-in-situ-lcis\/\" class=\"elementor-item\">Lobular Carcinoma in Situ (LCIS)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2527\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/early-life-exposures\/\" class=\"elementor-item\">Early Life Exposures<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-857c29f\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2525\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-men\/\" class=\"elementor-item\" tabindex=\"-1\">BRCA1 and BRCA2 Mutations in Men<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2526\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-women\/\" class=\"elementor-item\" tabindex=\"-1\">BRCA1 and BRCA2 Mutations in Women<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2528\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/lobular-carcinoma-in-situ-lcis\/\" class=\"elementor-item\" tabindex=\"-1\">Lobular Carcinoma in Situ (LCIS)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2527\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/early-life-exposures\/\" class=\"elementor-item\" tabindex=\"-1\">Early Life Exposures<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2330\" class=\"elementor-element elementor-element-8382bf4 e-con-full e-flex e-con e-child\" data-id=\"8382bf4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f24ff62 elementor-widget elementor-widget-heading\" data-id=\"f24ff62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Benign Breast Conditions<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e396cf6 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"e396cf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"\u30e1\u30cb\u30e5\u30fc\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none\">\n\t\t\t\t<ul id=\"menu-1-e396cf6\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-7721\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/chemo-side-effects\/\" class=\"elementor-item\">Chemo side effects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2529\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/patient-faq\/\" class=\"elementor-item\">Patient FAQ<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-e396cf6\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-7721\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/chemo-side-effects\/\" class=\"elementor-item\" tabindex=\"-1\">Chemo side effects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2529\"><a href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/patient-faq\/\" class=\"elementor-item\" tabindex=\"-1\">Patient FAQ<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6972075 e-con-full e-flex e-con e-child\" data-id=\"6972075\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c81c7a elementor-widget elementor-widget-heading\" data-id=\"2c81c7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">BRCA1 and BRCA2 Mutations in Men<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30c450a elementor-widget elementor-widget-text-editor\" data-id=\"30c450a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>BRCA1 and BRCA2 are genes that help repair damaged DNA and protect against cancer. Harmful (pathogenic) mutations in these genes can be inherited by men and women. Although men generally have lower cancer risks than women, BRCA mutations can still have important health implications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-50d0e49 e-con-full e-flex e-con e-child\" data-id=\"50d0e49\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-89eb267 elementor-widget elementor-widget-heading\" data-id=\"89eb267\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What does it mean for men to carry a BRCA mutation?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-758925d color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"758925d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li>BRCA mutations can be inherited from either parent<\/li><li>Each child of a parent with a BRCA mutation has a 50% chance of inheriting it<\/li><li>Men may have no symptoms, but can still pass the mutation to their children<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e9de67 e-con-full e-flex e-con e-child\" data-id=\"5e9de67\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0179e61 elementor-widget elementor-widget-heading\" data-id=\"0179e61\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cancer risks for men with BRCA mutations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d343b1 color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"1d343b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Risks vary by gene and family history:<\/span><\/span><\/p><ul><li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Male breast cancer<\/span><\/span><\/strong><ul><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">BRCA1: about 1\u20132% lifetime risk<\/span><\/span><\/li><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">BRCA2: about 6\u20138% lifetime risk (much higher than average)<\/span><\/span><\/li><\/ul><\/li><li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Prostate cancer<\/span><\/span><\/strong><ul><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">BRCA1: moderately increased risk<\/span><\/span><\/li><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">BRCA2: significantly increased risk, often earlier and more aggressive<\/span><\/span><\/li><\/ul><\/li><li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Pancreatic cancer<\/span><\/span><\/strong><ul><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Increased risk with both BRCA1 and BRCA2<\/span><\/span><\/li><\/ul><\/li><li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Melanoma<\/span><\/span><\/strong><ul><li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Higher risk, particularly with BRCA2<\/span><\/span><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9018be4 e-con-full e-flex e-con e-child\" data-id=\"9018be4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-86b1f89 elementor-widget elementor-widget-heading\" data-id=\"86b1f89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Who should consider genetic testing?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe306be color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"fe306be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Men may be advised to consider genetic counseling and testing if they have:<\/p><ul><li>Male breast cancer at any age<\/li><li>Prostate cancer diagnosed at a younger age or with aggressive features<\/li><li>A family history of breast, ovarian, pancreatic, or prostate cancer<\/li><li>A known BRCA mutation in the family<\/li><li>Ashkenazi Jewish ancestry with a relevant family history<\/li><\/ul><p>Testing is usually done after genetic counseling to understand what the results may mean.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20df81b e-con-full e-flex e-con e-child\" data-id=\"20df81b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ade7852 elementor-widget elementor-widget-heading\" data-id=\"ade7852\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Screening and risk management for men<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1fe2ca color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"e1fe2ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Men with a BRCA mutation may benefit from:<\/p><ul><li>Clinical breast exams<br \/>Increased breast awareness<\/li><li>Prostate cancer screening starting earlier than average<\/li><li>Consideration of pancreatic cancer screening in certain high-risk families<\/li><li>Regular skin checks for melanoma<\/li><\/ul><p>Specific screening plans should be personalized with a healthcare provider.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e8dbac e-con-full e-flex e-con e-child\" data-id=\"5e8dbac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6b5483b elementor-widget elementor-widget-heading\" data-id=\"6b5483b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Why this matters for families<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d989ade color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"d989ade\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Even if a man never develops cancer, knowing his BRCA status can be critical for:<\/p><ul><li>Informing children and relatives who may also be at risk<\/li><li>Making informed health and family decisions<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a95c8dc e-con-full e-flex e-con e-child\" data-id=\"a95c8dc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6c2c476 e-con-full e-flex e-con e-child\" data-id=\"6c2c476\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-52ce312 e-con-full e-flex e-con e-child\" data-id=\"52ce312\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-430f0af elementor-widget elementor-widget-heading\" data-id=\"430f0af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Takeaway<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ccb1e1b elementor-widget elementor-widget-heading\" data-id=\"ccb1e1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">BRCA mutations are not just a women\u2019s issue. <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c97bca8 e-con-full e-flex e-con e-child\" data-id=\"c97bca8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06449c0 color-bullet-list elementor-widget elementor-widget-text-editor\" data-id=\"06449c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>For men, understanding genetic risk can lead to earlier screening, better outcomes, and lifesaving information for family members.<\/p><p>If you are concerned about your personal or family history, talk with a healthcare provider or genetic counselor.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Table of Contents About Breast Cancer BRCA1 and BRCA2 are genes that help repair damaged DNA and protect against cancer. Harmful (pathogenic) mutations in these genes can be inherited by men and women. Although men generally have lower cancer risks than women, BRCA mutations can still have important health implications. What does it mean for [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":27,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1868","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BRCA1 and BRCA2 Mutations in Men - RFTC Japan<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rftcjapan.org\/en\/about-breast-cancer\/brca1-and-brca2-mutations-in-men\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BRCA1 and BRCA2 Mutations in Men - RFTC Japan\" \/>\n<meta property=\"og:description\" content=\"Table of Contents About Breast Cancer BRCA1 and BRCA2 are genes that help repair damaged DNA and protect against cancer. 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